Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia
Identifieur interne : 000807 ( Main/Exploration ); précédent : 000806; suivant : 000808Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia
Auteurs : Juergen Falkensammer [Autriche] ; Tatjana Stojakovic [Autriche] ; Kurt Huber [Autriche] ; Angelika Hammerer-Lercher [Autriche] ; Ingrid Gruber [Autriche] ; Hubert Scharnagl [Autriche] ; Gustav Fraedrich [Autriche] ; Wolfram Santner [Autriche] ; Michael Schocke [Autriche] ; Andreas Greiner [Autriche]Source :
- Clinical Chemical Laboratory Medicine [ 14374331 ] ; 2007-04-01.
Abstract
Background: Ischemia-modified albumin (IMA) is an emerging marker of ischemia. To investigate the applicability of IMA for the diagnosis of skeletal muscle ischemia, we examined IMA changes as measured by the albumin-cobalt binding test, in a group of healthy volunteers after standardized exercise-induced calf muscle ischemia. Methods: A total of 12 healthy volunteers underwent standardized exercise on a plantar flexion pedal. Ischemic conditions were achieved by inflating a femoral blood pressure cuff at incremental pressures of 0, 60, 90, 120 and 150 mm Hg. Calf muscle ischemia was identified by synchronous 31P magnetic resonance spectroscopy, measuring intracellular concentrations of phosphocreatine (PCr) and inorganic phosphate (Pi). In addition, IMA, serum albumin, lactate, troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured at baseline and at 5, 10, 30, 360 and 720 min after cuff release. Results: Magnetic resonance spectroscopy showed calf muscle ischemia in all participants upon exercise and cuff inflation. Circulating IMA concentrations increased significantly after cuff release (p=0.03) and returned to baseline within 30 min. While we found a significant negative correlation with albumin, there was no association of IMA levels with lactate or intracellular levels of PCr or Pi in samples obtained at baseline and post-ischemia. TnT and NT-proBNP remained within the normal range throughout the observation period in all participants. Conclusions: IMA may represent a clinical marker for skeletal muscle ischemia, although its lack of specificity requires careful clinical interpretation of data. The short period of IMA elevation after ischemic exercise requires standardized conditions for use as a diagnostic tool and hints at IMA applicability as a marker of prolonged or chronic ischemia. Clin Chem Lab Med 2007;45:535–40.
Url:
DOI: 10.1515/CCLM.2007.087
Affiliations:
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last="Santner">Wolfram Santner</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Radiology, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Schocke, Michael" sort="Schocke, Michael" uniqKey="Schocke M" first="Michael" last="Schocke">Michael Schocke</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Radiology, Medical University Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Greiner, Andreas" sort="Greiner, Andreas" uniqKey="Greiner A" first="Andreas" last="Greiner">Andreas Greiner</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Division of Vascular Surgery, Medical University Innsbruck, 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type="ISSN">14374331</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Ischemia-modified albumin (IMA) is an emerging marker of ischemia. To investigate the applicability of IMA for the diagnosis of skeletal muscle ischemia, we examined IMA changes as measured by the albumin-cobalt binding test, in a group of healthy volunteers after standardized exercise-induced calf muscle ischemia. Methods: A total of 12 healthy volunteers underwent standardized exercise on a plantar flexion pedal. Ischemic conditions were achieved by inflating a femoral blood pressure cuff at incremental pressures of 0, 60, 90, 120 and 150 mm Hg. Calf muscle ischemia was identified by synchronous 31P magnetic resonance spectroscopy, measuring intracellular concentrations of phosphocreatine (PCr) and inorganic phosphate (Pi). In addition, IMA, serum albumin, lactate, troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured at baseline and at 5, 10, 30, 360 and 720 min after cuff release. Results: Magnetic resonance spectroscopy showed calf muscle ischemia in all participants upon exercise and cuff inflation. Circulating IMA concentrations increased significantly after cuff release (p=0.03) and returned to baseline within 30 min. While we found a significant negative correlation with albumin, there was no association of IMA levels with lactate or intracellular levels of PCr or Pi in samples obtained at baseline and post-ischemia. TnT and NT-proBNP remained within the normal range throughout the observation period in all participants. Conclusions: IMA may represent a clinical marker for skeletal muscle ischemia, although its lack of specificity requires careful clinical interpretation of data. The short period of IMA elevation after ischemic exercise requires standardized conditions for use as a diagnostic tool and hints at IMA applicability as a marker of prolonged or chronic ischemia. Clin Chem Lab Med 2007;45:535–40.</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="Autriche"><noRegion><name sortKey="Falkensammer, Juergen" sort="Falkensammer, Juergen" uniqKey="Falkensammer J" first="Juergen" last="Falkensammer">Juergen Falkensammer</name></noRegion><name sortKey="Fraedrich, Gustav" sort="Fraedrich, Gustav" uniqKey="Fraedrich G" first="Gustav" last="Fraedrich">Gustav Fraedrich</name><name sortKey="Greiner, Andreas" sort="Greiner, Andreas" uniqKey="Greiner A" first="Andreas" last="Greiner">Andreas Greiner</name><name sortKey="Gruber, Ingrid" sort="Gruber, Ingrid" uniqKey="Gruber I" first="Ingrid" last="Gruber">Ingrid Gruber</name><name sortKey="Hammerer Lercher, Angelika" sort="Hammerer Lercher, Angelika" uniqKey="Hammerer Lercher A" first="Angelika" last="Hammerer-Lercher">Angelika Hammerer-Lercher</name><name sortKey="Huber, Kurt" sort="Huber, Kurt" uniqKey="Huber K" first="Kurt" last="Huber">Kurt Huber</name><name sortKey="Santner, Wolfram" sort="Santner, Wolfram" uniqKey="Santner W" first="Wolfram" last="Santner">Wolfram Santner</name><name sortKey="Scharnagl, Hubert" sort="Scharnagl, Hubert" uniqKey="Scharnagl H" first="Hubert" last="Scharnagl">Hubert Scharnagl</name><name sortKey="Schocke, Michael" sort="Schocke, Michael" uniqKey="Schocke M" first="Michael" last="Schocke">Michael Schocke</name><name sortKey="Stojakovic, Tatjana" sort="Stojakovic, Tatjana" uniqKey="Stojakovic T" first="Tatjana" last="Stojakovic">Tatjana Stojakovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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